1/18/2024 0 Comments Sodium normal range at 146In this study, we measured serum electrolyte levels in Chinese subjects with diabetes, to investigate the relationship between electrolytes and glucose levels, and we focus on examining the differences in serum electrolytes in diabetic patients with or without macrovascular complications.Ī gender- and age- matched case–control analysis was performed based on data obtained from the follow-up study of the Shanghai Diabetes Study (SHDS) and SHDS II. However, scant data are available on serum electrolyte levels in Chinese adults with diabetes, especially in those with cardiovascular complications, such as cardiovascular disease (CVD) events and peripheral arterial disease (PAD). The prevalence of DM in China is increasing rapidly. The Atherosclerosis Risk in Communities (ARIC) study has shown an association between low serum magnesium level and an increased risk of ischemic stroke in African Americans and Caucasians. In addition, hypomagnesemia and diuretic-associated hypokalemia may lead to a higher incidence of DM, mild electrolyte changes such as low Mg 2+ levels can predict mortality in type 2 DM and oral magnesium supplementation reduces fasting plasma glucose levels in DM patients. Disturbances in the levels of some electrolytes are associated with diabetes mellitus (DM). Serum concentrations of electrolytes have been shown to change with plasma glucose levels. These electrolytes play an important role in intermediary metabolism and cellular function, including enzyme activities and electrical gradients. The electrolytes in serum include sodium (Na +), potassium (K +), calcium (Ca 2+) and magnesium (Mg 2+). Diabetic patients with macrovascular complications had lower serum magnesium level than those with no macrovascular complications. Serum sodium and magnesium levels were decreased in Chinese subjects with diabetes, while the observed increase in calcium level correlated with increasing glucose level. ANCOVA analysis suggested that serum magnesium level in subjects with diabetic macrovascular complications was significantly decreased compared with diabetic subjects without macrovascular complications after the effect of some possible confounding being removed ( P < 0.05). In diabetic subjects, serum sodium, magnesium and potassium levels were decreased in the subjects with the elevation of estimated glomerular filtration rates ( P < 0.05). Multiple linear regression showed that serum sodium and magnesium levels in the diabetes group were negatively correlated with FPG, 2hPG and HbA1c (sodium: Std β = −0.35, -0.19, -0.25 magnesium: Std β = −0.29, -0.17, -0.34, all P < 0.01), while the serum calcium level was positively correlated with HbA1c (Std β = 0.17, P < 0.05). Serum sodium and magnesium levels in the diabetes group were significantly decreased compared to the NGR group (sodium: 141.0 ± 2.4 vs. Data collection included ankle brachial index results. Fasting plasma glucose (FPG), 2-hour post-load plasma glucose (2hPG), glycosylated hemoglobin A1c (HbA1c) and serum electrolyte levels were measured. The three gender- and age-matched groups were enrolled into this analysis, which were 1,170 subjects with normal glucose regulation (NGR), 389 with impaired glucose regulation (IGR) and 343 with diabetes. This study measured serum electrolyte levels and examined their relationship with macrovascular complications in Chinese adults with diabetes. However, scarce data are available on serum electrolyte levels in Chinese adults with diabetes, especially in those with cardiovascular complications. The prevalence of diabetes in China is increasing rapidly.
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